Peripheral blood chromosome karyotype analysis in 2121 cases of genetic counseling

Objective: Analyze the type and incidence rate of chromosomal aberration in cases of genetic counseling and explore the application value of cytogenetic examination in clinical diagnosis.Methods: Peripheral blood specimens obtained from cases were cultured for chromosome karyotype analysis.Results: Among 2121 cases of genetic counseling,1278 cases had the history of abnormal pregnancy;568 cases were with aspermia,asthenospermia or oligospermia;119 cases were infertile;46 cases suffered from sexual abnormality;48 cases had amenorrhea or irregular menstruation;62 cases received health counseling before pregnancy.141 cases were found with abnormal chromosome karyotype,and the incidence rate of chromosomal aberration was 6.65%.Conclusion: Abnormal fertility is the most common cause of genetic counseling,and the result of karyotype analysis is the important reference for clinical diagnosis and prepotency.