Peripheral blood lymphocyte subsets of patients with inflammatory bowel disease before and after drug treatment activities

Objective To explore the peripheral blood lymphocyte subsets of patients with inflammatory bowel disease before and after drug treatment activities with infliximab. Methods Twenty- three patients with active inflammatory bowel disease,who were treated in Jingyang Hospital of Maternal and Chinld Healthcare from June 2010 to May 2014,were selected and assigned into ulcer colitis group( UC) and Crohn's disease group( CD group),and another 23 healthy persons were selected during the same period as healthy group.We pbserved the drug efficacy before and after treatment,and the changes of peripheral blood lymphocyte subsets in patients,inflammatory reaction,and compared the lymphocytes subsets level between the effective treatment group and the ineffective treatment group. Results Of 15 cases in UC group,5 cases( 33. 33%) clinically remitted,3 cases( 20. 00%) improved,7 cases( 46. 67%) invalid. The total effective rate was 53. 33%. Of 8 cases in group CD,1 case( 12. 50%) clinically remitted,5 cases( 62. 50%) improved,2 cases( 25%) invalid. The total effective rate was 75%. Before and after treatment CD3+,CD4+,CD4+/ CD8+,NK in UC group were lower than those in the healthy group. The above- mentioned indexes increased after treatment,and there were no statistical differences in CD3+,CD4+between UC group and the healthy group( P 0. 05). Before treatment,there were significant differences in CD3+,CD4+,CD8+,CD4+/ CD8+and NK between CD group and the healthy group( P 0. 05). After treatment CD3+,CD4+,CD4+/CD8+and NK increased significantly,and there were no significant differences between CD group and the healthy group( P 0. 05).There was no significant difference in CD4+between the effective treatment group and the ineffective treatment group,while CD3+,CD4+/ CD8+,NK were higher and CD8+was significantly lower in effective treatment group with significant differences( P 0. 05).Conclusions After the treatment with infliximab,the level of CD8+in patients was decreased,while the levels of CD3+,CD4+,CD4+/ CD8+and NK were increased,close to the normal level.