Clinical Significance of Detection of Plasma Natriuretic Peptide in the Diagnosis of Patients with Heart Failure

To explore the clinical significance of plasma natriuretic peptide in the diagnosis of patients with heart failure (HF), the plasma atrial natriuretic peptide (ANP) ,brain natriuretic peptide (BNP),NT-pro brain natriuretic peptide (NT-proBNP) levels in 129 patients with heart failure and 30 healthy controls were detected by RIA and ELISA. The results showed that the plasma ANP, BNP,NT -proBNP levels in patients with heart failure were significantly higher than the healthy controls. As the cardiac function deteriorated from NYHAⅠ toⅣ,the BNP and NT-proBNP levels increased consecutively with significant differences from each other. There was a negative correlation between the plasma ANP and NT-proBNP levels and LVEF. The determination of plasma ANP,BNP and NT-proBNP levels in patients with HF were helpful to the study of the severity and diagnosis of disease.