Research Progress on Mechanism of Insect Resistance to Insecticides

Drug resistance in insects has become a major problem faced by pest control in agriculture and forestry due to long term use of insecticides.Studies on insect resistance mechanism could provide scientific guidance for prevention and control of agricultural and forestry pests,selection and breeding of resistant strains in resource insect,and exploitation of novel insecticides.Primary understanding on the metabolic resistance and target-site resistance has been obtained through studying the model insects,medical insects,agricultural and forestry pests.And a number of genes related to drug resistance have been cloned and analyzed using molecular biological methods.At present,further research is being conducted to elucidate mechanism of insect resistance to insecticides in view of genomics.Based on the research achievements of recent years,this article summarizes physiological,biochemical,and molecular mechanisms contributing to the formation of drug resistance with emphasis on analyzing the major detoxification enzymes involved in drug resistance.