ScholarLens Back to search
2001•Zhonghua weizhongbing jijiu yixueRequires access

Nestin as an early sensitive marker for hippocampus injury following transient cerebral ischemia in rats

Yao Zhi-bi

Open publisher page 0 citations

Abstract

Objective:To investigate the early Nestin expression in hippocampus in rats following the transient cerebral ischemia.Methods:Male SpragueDawley rats were divided into normal control,sham operation control and injury group.Animals in injury group were subjected to four vessels occlusion operation,and then were subdivided into 1,3,7,14 and 21 days groups according to the time elapsed after injury.The expression of Nestin and glial fibrillary acidic protein (GFAP) were determined by immunohistochemistry.Results:The numbers of Nestin positive cells increased bilaterally in hippocampus on day one postinjury,peaked on day seven and then returned to the normal level on day 14 postinjury.The numbers of GFAP positive cells slightly increased on day three,peaked on day seven and then decreased.Conclusions:Nestin is an early sensitive molecular marker for hippocampus injury following transient cerebral ischemia in rats.

About this research paper

What this paper is about

Objective:To investigate the early Nestin expression in hippocampus in rats following the transient cerebral ischemia.Methods:Male SpragueDawley rats were divided into normal control,sham operation control and injury group.Animals in injury group were subjected to four vessels occlusion operation,and then were subdivided into 1,3,7,14 and 21 days groups according to the time elapsed after injury.The expression of Nestin and glial fibrillary acidic protein (GFAP) were determined by immunohistochemistry.Results:The numbers of Nestin positive cells increased bilaterally in hippocampus on day one postinjury,peaked on day seven and then returned to the normal level on day 14 postinjury.The numbers of GFAP positive cells slightly increased on day three,peaked on day seven and then decreased.Conclusions:Nestin is an early sensitive molecular marker for hippocampus injury following transient cerebral ischemia in rats.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective:To investigate the early Nestin expression in hippocampus in rats following the transient cerebral ischemia.Methods:Male SpragueDawley rats were divided into normal control,sham operation control and injury group.Animals in injury group were subjected to four vessels occlusion operation,and then were subdivided into 1,3,7,14 and 21 days groups according to the time elapsed after injury.The expression of Nestin and glial fibrillary acidic protein (GFAP) were determined by immunohistochemistry.Results:The numbers of Nestin positive cells increased bilaterally in hippocampus on day one postinjury,peaked on day seven and then returned to the normal level on day 14 postinjury.The numbers of GFAP positive cells slightly increased on day three,peaked on day seven and then decreased.Conclusions:Nestin is an early sensitive molecular marker for hippocampus injury following transient cerebral ischemia in rats.

Key concepts: Nestin, Glial fibrillary acidic protein, Medicine, Ischemia, Hippocampus, Immunohistochemistry, Pathology, Brain ischemia

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Nestin as an early sensitive marker for hippocampus injury following transient cerebral ischemia in rats — Research Paper | ScholarLens