Efficacy and influence of losartan on blood pressure T/P in patients with essential hypertension by ambulatory blood pressure monitoring

Objective: To evaluate the antihypertensive efficacy and influence of losartan on blood pressure (BP) T/P in patients with essential hypertension (EH) by ambulatory blood pressure monitoring. Methods: Sixty EH patients were enrolled randomly divided into losartan group (30 cases) and benazepril group (30 cases). Losartan (50-100 mg) was given to losartan group once/d for 16 weeks. Benazepril (10-20 mg) was given to benazepril group once/d for 16 weeks. Results: After treatment BP significantly decreased in both groups. SBP decreased from 168. 2±16. 3 mmHg to 138. 3±17. 2 mmHg, DBP decreased from 99. 8±8. 1 mmHg to 85. 3±6. 4 mmHg; T/P of SBP, DBP was 0. 73 and 0. 68 in losartan group. SBP decreased from 169. 4±16. 7 mmHg to 139. 3±16. 0 mmHg, DBP decreased from 98. 7 ± 9. 2 mmHg to 84. 6±6. 3 mmHg;T/P of SBP,DBP was 0. 67 and 0. 63 in benazepril group (compared with before treatment P0. 01 all ). No significantly difference between two groups for BP (P0. 05). There were no significant side effects in losantan group, but there was serve cough in 2 patients of benazepril group. Conclusion: Losartan is effective, safe and well tolerated in EH treatment. Its efficacy is analogous to that of benazepril but its side effects is less.