The expression of LFA-1 and Mac-1 on acute myeloid leukemia cells

Objective To evaluate the effects of CD11a and CD11b expression on the hyperleukocytosis and infiltration of AML,and to observe CD11a and CD11b expression on AML blast cells.Methods Flow cytometry was used to investigate CD11a and CD11b expression on AML blast cells;The correlations of CD11a and CD11b expression with the clinical features of AML patients ware evaluated.Results The expression of CD11a and CD11b on AML blast cells from 51 patients were(36.476±22.641)% and(26.955±12.328)%,respectively,and the expression of CD11a and CD11b on normal bone marrow mononuclear cells were(19.625±12.328)% and(15.513±6.296)%,respectively.The expression of CD11a and CD11b were not significantly different on each subtype.The expression of CD11a,CD11b and WBC were significantly positive correlated.In the positive CD11a(≥20 %)and CD11b(≥30 %)expression of the patients,WBC and the rate of infiltration were higher and the rate of CR ware lower than that in the negative CD11a and CD11b expression of the patients.Conclusion The expressions of LFA-1 and Mac-1 on patients of AML were increased significantly,which are related tightly to the some characteristics of AML.The increased expression of LFA-1 and Mac-1 on AML are contributed to higher WBC and higher infiltration and lower CR rate.The increased expression of LFA-1 and Mac-1 on AML were considered as a poor prognosis factors.