Mohnarin 2009 annual report:Bacterial distribution and resistance surveillance in wound infections

Objective To investigate the bacterial distribution and antibiotic resistance of wound infections in 114 hospitals during 2009 in China.Methods Disc diffusion test,MIC test and E-test were used to study the antimicrobial resistance.WHONET 5.5 was applied for analysis the antibacterial sensitive data.Results A total of 6171 isolates were isolated from wound infections,including 2728(44.2%) Gram-positive strains and 3443(55.8%) Gram-negative strains.The top six pathogens were Staphylococcus aureus(19.8%),Escherichia coli(16.9%),Pseudomonas aeruginosa(8.9%),Klebsiella pneumoniae(8.0%),Staphylococcus epidermidis(6.7%) and Acinetobacter baumannii(5.2%).Methicillin-resistant strains in Staphylococcus aureus and Staphylococcus epidermidis accounted for 31.0% and 65.1%,respectively.No Staphylococcus spp.was intermediate or resistant to vancomycin and linezolid.The intermediate rate of Staphylococcus epidermidis to teicoplanim was 1.2%.Enterococcus faecium had higher resistant rates to almost all the antibiotics than Enterococcus faecalis.The resistant rates of Enterococcus faecalis and Enterococcus faecium to vancomycin(VRE) were 0.5% and 1.5%.One point three percent of Enterococcus faecium were resistant to teicoplanin.No Enterococcus isolate was resistant to linezolid.ESBLs-producing strains accounted for 65.5% in Escherichia coli and 40% in Klebsiella pneumoniae.Escherichia coli had higher resistant rates to almost all the antibiotics than Klebsiella pneumoniae.More than 43% of Acinetobacter baumannii was resistant to most of the tested drugs.The resistance rate of Pseudomonas aeruginosa and Acinetobacter baumannii to imipenem was 17.2% and 33.8%,respectively.Conclusion Escherichia coli,Staphylococcus spp.and Pseudomonas aeruginosa were predominant pathogens in wound infections in China.The bacterial resistance was a serious problem in China.The resistance of pathogens should be monitored to provide practical guidance of rational selection of antibiotics for clinicians.