Detection of △Np63 in Skin Malignant and Benign Proliferative Diseases

Objective To investigate the expression of △Np63 in skin malignant and benign proliferative diseases. Methods The expressions of △Np63 in seborrheic keratosis(n=30), actinic keratosis(n=30), basal cell carcinoma(n=30) and normal skin(n=10) tissues were detected by immunohistochemical method and were compared by Image-Pro Plus6.0 (IPP) Image analysis software which was used for quantitative determination of each field of vision of positive expression of the average optical density (density mean). Results The average optical density of △Np63 expression in seborrheic keratosis was 0.0391±.0169; while it was 0.0262±0.0184 in actinic keratosis; 0.0498±.0222 in basal cell carcinoma; 0.0056±.0019 in normal skin. There was not statistically significant difference between the group of seborrheic keratosis and basal cell carcinoma(P0.05), while there was statistically significant difference between other two groups(P0.05). There was not statistically significant difference among different positions of each studied disease for the average optical density of △Np63 protein (P0.05). Conclusion △Np63 expression is a valuable immunohistochemical maker for undifferentiated tumors of epithelial cell origin.