Clinical significance of PSMA gene expression in prostate cancer tissue

Objective To investigate the expression of prostate specific membrane antitagen(PSMA) in prostate cancer tissue and its significance.Methods Expression of PSMA was assayed by semiquantitative RT-PCR in 52 cases of prostate cancer and 35 cases of benign prostatic hyperplasia tissues.Results(1)The positive rates of PSMA in the tissues of prostate cancer and benign prostatic hyperplasia were 84.6% and 68.6% respectively.Although there was no statistical difference between the two sets of positive rate,the semiquantitative results showed that the expression level of PSMA in prostate cancer was significantly higher than that in benign prostatic hyperplasia tissues.(2)The expression quantity of PSMA was correlated with histological grade,the expression quantity of PSMA was lower in well-differentiated endometrial carcinoma than in poorly differentiated endometrial carcinoma.Conclusion Expression of PSMA in prostate cancer is related with the differentiation degree of tumor and is higher than that in prostatic hyperplasia tissues,which prompts that PSMA may be used as an index to assess the differentiation degree and prognosis of prostate cancer.