Study on HLA-DR and ICAM-1 in pathogenesis of endometriosis

Objective:To detect the expressions of human leukocyte antigen-DR molecule(HLA-DR)and intercellular adhesion molecule-1(ICAM-1)in ectopic endometrium and eutopic endometrium of patients with endometriosis,explore the significance of HLA-DR and ICAM-1 in immune pathogenesis of endometriosis.Methods:The expression levels of HLA-DR and ICAM-1 in ectopic endometrium and eutopic endometrium of patients with endometriosis and normal endometrium of control group were detected by immunohistochemical SP method.Results:The expression levels of HLA-DR and ICAM-1 in ectopic endometrium of patients with endometriosis were significantly higher than those in eutopic endometrium of patients with endometriosis and normal endometrium of control group(P0.05);there was no significant difference in expression levels of HLA-DR and ICAM-1 between eutopic endometrium of patients with endometriosis and normal endometrium of control group(P0.05);the expression levels of HLA-DR and ICAM-1 in eutopic endometrium of patients with endometriosis changed periodically,the expression levels in proliferative phase were significantly higher than those in secretory phase(P0.05);in normal endometrium of control group,the expression levels of HLA-DR and ICAM-1 in proliferative phase were higher than those in secretory phase,but there was no significant difference(P0.05);in ectopic endometrium and eutopic endometrium of patients with endometriosis,there was a positive correlation between expression of HLA-DR and ICAM-1.Conclusion:The expression levels of HLA-DR and ICAM-1 in ectopic endometrium of patients with endometriosis increase,the abnormal changes induce the changes of peritoneal local immune microenvironment in patients with endometriosis and promote the occurrence and development of endometriosis.