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2011•Journal of Emergency in Traditional Chinese MedicineRequires access

Expression of IL-1 and TNF-α in Adjuvant Arthritis Rats Modles

Shujie Wang

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Abstract

Objective:To detect the expression characteristice of IL-1 and TNF-α in adjuvant arthritis(AA) rats model.Methods:AA rats model was established,the the serum level of IL-1 and TNF-α were determined by ELISA and the degree of pathogenicity as well as the pathological characteristice were assayed by histopathological techniques and joint roentgenography.Results:Compared with the control group,the IL-1 and the TNF-α were increased obviously in the model group.Conclusion:The serum level of IL-1 and TNF-α might involve in the pathogenesis of rheumatoid arthritis.

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What this paper is about

Objective:To detect the expression characteristice of IL-1 and TNF-α in adjuvant arthritis(AA) rats model.Methods:AA rats model was established,the the serum level of IL-1 and TNF-α were determined by ELISA and the degree of pathogenicity as well as the pathological characteristice were assayed by histopathological techniques and joint roentgenography.Results:Compared with the control group,the IL-1 and the TNF-α were increased obviously in the model group.Conclusion:The serum level of IL-1 and TNF-α might involve in the pathogenesis of rheumatoid arthritis.

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Available abstract

Objective:To detect the expression characteristice of IL-1 and TNF-α in adjuvant arthritis(AA) rats model.Methods:AA rats model was established,the the serum level of IL-1 and TNF-α were determined by ELISA and the degree of pathogenicity as well as the pathological characteristice were assayed by histopathological techniques and joint roentgenography.Results:Compared with the control group,the IL-1 and the TNF-α were increased obviously in the model group.Conclusion:The serum level of IL-1 and TNF-α might involve in the pathogenesis of rheumatoid arthritis.

Key concepts: Medicine, Rheumatoid arthritis, Pathogenesis, Arthritis, Pathological, Tumor necrosis factor alpha, Adjuvant, Immunology

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