2011•Huanjing yu zhiye yixueRequires access

DNA Oxidative Damage and Cancer

Xinxin Li, Gonghuan Yang

Abstract

DNA damage induced by oxidative stress/lipid peroxidation may play an important role for driving normal cells to malignancy in the occurrence of human cancers.This review summarized the lipid peroxidation-induced DNA damage and its detection methods.DNA adducts could be applied as biomarkers of oxidative stress/lipid peroxidation in the study of the etiology and prevention of cancer.

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Available abstract

Key concepts: Lipid peroxidation, Oxidative stress, DNA damage, Oxidative damage, DNA, Cancer, Comet assay, Oxidative phosphorylation