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2010•Proceeding of Clinical MedicineRequires access

Inhibitive action of atorvastatin on CD40L,MMP-3 in ischemic brain tissue after reperfusion in rats

Guofang Xue

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Abstract

Objective:To study the neuroprotective mechanism of atorvastatin against the injury induced by cerebral ischemia-reperfusion.Methods:The middle cerebral artery was occluded with thread according to modified Zealonga′s method.Wistar rats were randomly divided into:sham-operation group(Sham group),ischemia-reperfusion group(IR group),atorvastatin treatment group(AT group).The expressions of CD40L,MMP-3 in brain tissues were measured by immunohistochemical methods.Results:The expressions of CD40L,MMP-3,neurologicol scores,subtract brainedema in AT group were lower than those in IR group(P0.01),significantly higher than those in sham group(P0.01).Conclusion:Atorvastatin can protect neural function by downregulating CD40L、MMP-3 expressions during focal cerebral ischemia-reperfusion.

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What this paper is about

Objective:To study the neuroprotective mechanism of atorvastatin against the injury induced by cerebral ischemia-reperfusion.Methods:The middle cerebral artery was occluded with thread according to modified Zealonga′s method.Wistar rats were randomly divided into:sham-operation group(Sham group),ischemia-reperfusion group(IR group),atorvastatin treatment group(AT group).The expressions of CD40L,MMP-3 in brain tissues were measured by immunohistochemical methods.Results:The expressions of CD40L,MMP-3,neurologicol scores,subtract brainedema in AT group were lower than those in IR group(P0.01),significantly higher than those in sham group(P0.01).Conclusion:Atorvastatin can protect neural function by downregulating CD40L、MMP-3 expressions during focal cerebral ischemia-reperfusion.

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Available abstract

Objective:To study the neuroprotective mechanism of atorvastatin against the injury induced by cerebral ischemia-reperfusion.Methods:The middle cerebral artery was occluded with thread according to modified Zealonga′s method.Wistar rats were randomly divided into:sham-operation group(Sham group),ischemia-reperfusion group(IR group),atorvastatin treatment group(AT group).The expressions of CD40L,MMP-3 in brain tissues were measured by immunohistochemical methods.Results:The expressions of CD40L,MMP-3,neurologicol scores,subtract brainedema in AT group were lower than those in IR group(P0.01),significantly higher than those in sham group(P0.01).Conclusion:Atorvastatin can protect neural function by downregulating CD40L、MMP-3 expressions during focal cerebral ischemia-reperfusion.

Key concepts: Atorvastatin, Ischemia, Medicine, Neuroprotection, Reperfusion injury, Immunohistochemistry, Anesthesia, Middle cerebral artery

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Inhibitive action of atorvastatin on CD40L,MMP-3 in ischemic brain tissue after reperfusion in rats — Research Paper | ScholarLens