Expression and Clinical Significance of Vascular Endothelial Growth Factor in Esophageal Carcinoma

Objective To approach the relationship among the vascular endothelial growth factor(VEGF),the angiogenesis and the clinical pathological characteristics of esophageal carcinoma.Methods Protein expressions of VEGF and MVD in 50 patients with esophageal cancer were determined by immunohistochemical staining.VEGF expressions were analyzed together with their relations to histologic type,depth of invasion,growth pattern,lymph node metastasis and distant metastasis.Results MVD was notable higher in VEGF -positive esophageal carcinoma than in negative group.The protein expressions of VEGF closely correlated with depth of invasion,lymph node metastasis.Their relations to the histologic types and growth pattern of esophageal carcinoma were also obviouse.Conclusion VEGF is closely related to angiogenesis of esophageal carcinoma and promotes its growth,invasion and metastasis.The expression of VEGF is one of the biological behavioral indexes of esophageal carcinoma.