2014•Academic Journal of Chinese PLA Medical SchoolRequires access
Haplo-hematopoietic stem cell transplantation in treatment of aplastic anemia-paroxysmal nocturnal hemoglobinuria syndome: A case report
XU Li-xi
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Abstract
Objective To study the haplo-hematopoietic stem cell transplantation in treatment of aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome(AA-PNH). Methods One patient with AA-PNH for 3 years admitted to our hospital in March 2011 underwent transplantation of haplo-hematopoietic stem cells from his mother. Grafts were selected from the mobilized haplohematopoietic bone marrow and peripheral blood. Human umbilical cord-derived mesenchymal stem cells(hUC-MSCs) were transferred as the third part of cells. Results The total number of mononuclear cells(MNC) and CD34+ cells was 10.8×108/kg and 4.8×106/kg, respectively. The number of neutrophils and platelets was 0.5×109/L and 20×109/L on days 37 and 58. The chimeras accounted for 100% on day 30 and grade 1 aGVHD was observed on about day 40, with no other severe complications occurred after treatment. Conclusion Haplo-hematopoietic stem cell transplantation is a safe and effective treatment modality for AA-PNH syndrome.