Study on effect of carbon dioxide pneumoperitoneum in laparoscopic cholecystectomy on liver function in elderly patients

Objective To observe the effect of carbon dioxide pneumoperitoneum on hepatic function in elderly patients undergoing laparoscopic cholecystectomy. Methods Fifty- two patients with ASAⅠorⅡ,aged 60 ~ 73 years,underwent laparoscopic cholecystectomy were randomly divided into two groups( n = 26 each) : low pneumoperitoneal pressure group( group L) with pressure at 9 ± 1 mmHg( group L) and standard pneumoperitoneum pressure group( group S) with pressure at 15 ± 1 mmHg. The indexes of liver function were measured and recorded in 24 h before operation and 2,24 and 72 hours after operation. Results The serum levels of ALT and AST in 2 h and 24 h after surgery in group L were higher than preoperative figures( P 0. 05). In comparison with group L,ALT,AST,GGT and LDH in 2 h and 24 h after surgery in group S were significantly elevated( P 0. 05). The indexes of these two groups were returned to preoperative level in 72 h after surgery. Conclusion Carbon dioxide pneumoperitoneum can cause transient abnormality of liver function in elderly patients undergoing laparoscopic cholecystectomy, and low pneumoperitoneum pressure is beneficial to protect liver function.