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2007•Journal of Hepatopancreatobiliary SurgeryRequires access

Influence of hepatectomy combined with hepaticer artery ligation and portal vein chemotherapy for hepatocellular carcinoma on the expression of MDR-1 and MRP and significance

YI Ji-li

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Abstract

Objecive To explore and discuss the influence of hepatectomy combined with hepatic artery ligation and portal vein chemotherapy for hepatocellular carcinoma on the expression of MDR-1 and MRP-1.Methods The expression of P-gp and MRP-1 in 23 specimen of recurrent HCC patients was determined with immunohistochemical method.The primary tumor tissues served as a control group and analyzed statistically.Results The positive rate of P-gp expression in HCC was 65.2% before recurrence and 52.2% after recurrence(P0.05),while that of MRP-1 expression was 34.8% and 69.5%,respectively(P0.05).Conclusion The expression of MDR-1 of the recurrent hepatocellular carcinoma is inhibited after hepatectomy combined with hepatic artery ligation and portal vein chemotherapy for hepatocellular carcinoma.

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Objecive To explore and discuss the influence of hepatectomy combined with hepatic artery ligation and portal vein chemotherapy for hepatocellular carcinoma on the expression of MDR-1 and MRP-1.Methods The expression of P-gp and MRP-1 in 23 specimen of recurrent HCC patients was determined with immunohistochemical method.The primary tumor tissues served as a control group and analyzed statistically.Results The positive rate of P-gp expression in HCC was 65.2% before recurrence and 52.2% after recurrence(P0.05),while that of MRP-1 expression was 34.8% and 69.5%,respectively(P0.05).Conclusion The expression of MDR-1 of the recurrent hepatocellular carcinoma is inhibited after hepatectomy combined with hepatic artery ligation and portal vein chemotherapy for hepatocellular carcinoma.

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Available abstract

Objecive To explore and discuss the influence of hepatectomy combined with hepatic artery ligation and portal vein chemotherapy for hepatocellular carcinoma on the expression of MDR-1 and MRP-1.Methods The expression of P-gp and MRP-1 in 23 specimen of recurrent HCC patients was determined with immunohistochemical method.The primary tumor tissues served as a control group and analyzed statistically.Results The positive rate of P-gp expression in HCC was 65.2% before recurrence and 52.2% after recurrence(P0.05),while that of MRP-1 expression was 34.8% and 69.5%,respectively(P0.05).Conclusion The expression of MDR-1 of the recurrent hepatocellular carcinoma is inhibited after hepatectomy combined with hepatic artery ligation and portal vein chemotherapy for hepatocellular carcinoma.

Key concepts: Hepatocellular carcinoma, Hepatectomy, Medicine, Ligation, Chemotherapy, Portal vein, Immunohistochemistry, Vein

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Influence of hepatectomy combined with hepaticer artery ligation and portal vein chemotherapy for hepatocellular carcinoma on the expression of MDR-1 and MRP and significance — Research Paper | ScholarLens