Research progress of effect of AQP-4 and Ca~(2+) on brain edema induced by cerebral hemorrhage

Brain edema induced by intracerebral hemorrhage is a common pathology process which can be divided into cell toxicity brain edema and vasogenic brain edema.The degree of edema occupied a very important position in the mechanism of cranial nerve damage secondary to cerebral hemorrhage.AQP-4 as transport passage of water and some small molecules channels,may increase cell toxicity brain edema,reduce vasogenic brain edema.Its mechanism may be related to the space specificity and time-dependence of the expression AQP-4.Ca2+ as a second messenger in cells,participates in the neurotransmitter's synthesis and release,the increase of its content can increase brain edema and make AQP-4 expression rising.AQP-4 as a signal access may also play a role in regulation of Ca2+.This paper reviewed the relevant research in recent years.