Influence of ozone concentration on the effect of interventional recanalization in the treatment of tubal obstructive infertility

Objective To discuss the influence of different concentrations of ozone on the effect of interventional recanalization in the treatment of infertility with tubal obstructive. Methods Two hundred patients with tubal obstruction infertility were divided into 4 groups(A, B, C, D) equally. Group A received conventional fallopian tube recanalization therapy. The other groups(B, C, D) received ozone combined with fallopian tube recanalization therapy. Group B, Group C and Group D were given low concentration of ozone(20 μg/ml), moderate concentration of ozone(40 μg/ml), and high concentration ozone(60 μg/ml) respectively. Discomforts occurring within 2 weeks after operation were scored. And after 6 months of follow-up, the intrauterine pregnancy rate was recorded, meanwhile, tubal reocclusion rate of non-pregnancy women were documented after tubal radiography. Results Scores of discomforts in four groups were(2.900 ±1.418),(2.140 ±1.246),(2.120 ±1.272), and(2.700 ±1.359) respectively, and there were differences between group A and group B, group A and group C, group B and group D, group C and group D(P0.05). However, there was no significant difference between group A and group D, group B and group C(P0.05). The pregnancy rates of four groups were 28.00%(14/50), 42.00%(21/50), 50.00%(25/50) and 54.00%(27/50) respectively, and there were differences between group A and group C, group A and group D(P0.05), however, there was no significant difference between group A and group B, group B and group C, group B and group D, group C and group D(P0.05). The reocclusion rate were 25.68%(19/74), 14.29%(10/70), 11.27%(8/71), and 8.57%(6/70), and there were differences between group A and group C, group A and group D(P0.05), however, there was no significant difference between group A and group B, group B and group C, group B and group D, group C and group D(P0.05).Conclusion Medical ozone can improve the effect of interventional fallopian tube recanalization in the treatment of infertility, and a moderate concentration(30~50 μg/ml) of ozone is regarded as the first choice.