Expression and Significance of CD4~+CD25~+ Regulatory T Cells in Idiopathic Thrombocytopenic Purpura

Objective To explore the expression and significance of CD4+CD25+ regulatory T cells in idiopathic thrombocytopenic purpura. Methods 33 patients with newly diagnosed ITP,22 ITP patients with post-treatment,and 20 health controls were studied.The expression of CD4+CD25high and CD4+CD25+CD127lowregulatory T cells were detected by flow cytometry.The patients with newly diagnosed ITP were further divided into groups with servious patients and group with mild patients.22 ITP patients with post-treatment were further divided into two groups with effective and ineffective treatment patients.Statistical analysis was carried out with regard to data in different groups.Results Compared to newly diagnosed ITP group and health controls,the levels of CD4+CD25high and CD4+CD25+CD127low regulatory T cells in newly diagnosed ITP group were significantly lower than those in health controls(P0.01),while the levels of servious group were markedly lower than those in mild group(P0.01,P0.05).The levels of CD4+CD25high and CD4+CD25+CD127low regulatory T cells in post-treatment group were significantly increased after treatment(P0.01),but still?lower than those in health controls(P0.05).The levels of CD4+CD25high and CD4+CD25+CD127low regulatory T cells in effective treatment group were significantly higher than those in ineffective group(P0.05).There were statistical significances in our results.Conclusion Detection of Treg expression has an important clinical significance in the pathogenesis and progrssion of ITP.