Study on correlation between expressions of ER、PR、HER-2 and the effect of neoadjuvant chemotherapy in breast cancer

Objective To study the correlation of biological markers ER、PR、HER-2 expression in breast cancer with the effect of neoadjuvant chemotherapy(NAC).To search predictive factors of NAC. Methods From Jun 2007 to Aug 2010,69 breast cancer patients in our hospital with NAC were enrolled in the sthdy.The expressions of ER、PR、HER-2 were detected by immunohistochemical method before NAC. Reponse rate was evaluated after 2～6 cycles of NAC.The correlation between expressions of biomarkers and the effect of NAC were analyzed.Results Among the 69 cases of NAC,the positive expression rate of ER、PR、HER-2 was 536%、507%、290%,respectively. The clinical reponse rate(RR) was 710%,with clinical completed response(cCR) was 304%,clinical partial reponse(cPR) was 406%,stable disease(SD) was 275%,progressive disease(PD) was 14%,pathologic complete reponse(pCR) was 58%. Conclusion In the breast cancer patients,ER, HER-2 negative tunors are more sensitive to NAC.ER, HER-2 can be considered as predictive markers of the effect of NAC.