Expression of Inhibitors of Differentiation-1 in Esophageal Squamous Cell Carcinoma Tissue and Its Significance

Objective To explore the expression of Idl protein in esophageal squamous cell carcinoma tissues(ESCC) and its significance.Methods The expression of Idl protein was detected by immunohistochemistry in 57 cases of ESCC tissue,34 cases of adjacent atypical hyperplasia epithelium and 57 cases of normal esophageal epithelium.Results The expression rates of Idl protein decreased by turns in carcinoma,adjacent atypical hyperplasia epithelium and normal esophageal epithelium specimens which were 54.4%(31/57),20~6%(7/34) and 0%(0/57) respectively.There was a significant statistic difference among the groups(P0.05).The expression of Idl protein was closely correlated with the different differentiation levels,infiltrative depth and lymphatic metastasis in ESCC tissue(P0.05).Conclusion The expression of Idl protein may play an important role in the infiltration,metastasis and carcinogenesis of ESCC,and can be used as a tumor maker of ESCC.United examining Idl protein has some clinical value in assessing the prognosis of ESCC.