The relationship between urokinase plasminogen activator system and non-Hodgkin lymphoma

Objection To investigate the relationship between urokinase plasminogen activator(uPA),urokinase-type plasminogen activators receptor(uPAR),plasminogen activator inhibitor type 1(PAI-1)in NHL patient's blood and NHL cell proliferation,invasion and prognosis.Methods The NHL patients plasma levels of uPA,uPAR and PAI-1 were measured by enzyme linked-immunoadsorbent assay(ELISA)in thirty-eight patients.We compared the NHL patients' uPA,uPAR and PAI-1 with healthy men as control group,parameters with different groups divided by clinical stage,the level of blood LDH with treatment affection.We also analyzed the correlationship between uPA,uPAR,PAI-1 and LDH in NHL patients.Results The levels of plasma uPA,uPAR and PAI-1 are remarkable higher in patients than the control group(P 0.05).The levels of plasma uPA and uPAR in the group of Ⅲ and Ⅳ clinical stage are higher than the group of Ⅰ and Ⅱ clinical stage,but have no significant difference(P 0.05).The levels of plasma uPAR is higher in the group of high Lactate dehydrogenase(LDH)than in the group of normal LDH(P 0.05).The levels of plasma uPA,uPAR and LDH are correlated significantly with each other(P 0.01).Conclusion The change in uPA system play an important role in NHL cell proliferation,invasion and prognosis.The levels of soluble uPAR(suPAR)can be used as the NHL load index and prognosis index in NHL patients.