Determination and Intervention with Simvastatin of Serum Transforming Growth Factor β_1、IV Collagens Levels in Early Diabetic Nephropathy

Objective To determine the serum levels of transforming growth factorβ1(TGF-β1)、 Ⅳ collagens(CⅣ) in early diabetic nephropathy and their intervention with simvastatin.Methods 88 type 2 diabetes patients were divided into two groups according to the level of urinary album in excretion rate(UAER),40 were diabetic patients without nephropathy(group DM) and 48 were patients with diabetic nephropathy(groupDN).48 patients of group DN were randomly divided into ruoutine group and simvastatin group.The levels of TGFβ1 and Ⅳcollagens were detected with ELISA,the 24-hour urinary album in excretion rate(UAER) were evaluated with radio-active immunoassay.Results Compared with DM patients,early DN patients showed significantly higher serum levels of TGF-β1、CⅣ(P0.05),which positively correlated with UAER(P0.05).Therapy with simvastatin resulted in significant reduction of serum TGF-β1 、CⅣ levels and UAER(P0.05).Conclusion Levels of TGF-β1 、CⅣ are elevated in early DN patients;simvastatin can decrease the levels of TGF-β1 、CⅣ and show it' protective effects on early diabetic nephropathy.