Evaluation on Different Immunization Schedules of Hepatitis A Vaccine Healive

With a view to evaluate the immunogenicity of different immunization schedules of the Healive D○R inactivated hepatitis A vaccine in five mountain area villages, 167 children aged 5～11 years old, seronegative for hepatitis A virus were randomly divided into five groups.Four groups administered 250U/dose vaccine according to 0、1,0、3,0、6 and 0、12 schedules respectively.The control group administered Havrix TM 720EIU inactivated hepatitis A vaccine. The results showed that the positive seroconversion rate were 97.0% and 95.5%,the geometric mean titers (GMTs) were 355mIU/ml and 251 mIU/ml,respectively by two and four weeks after the primary dose in trial groups.The seroconversion rate were all 100%, the GMTs were 417mIU/ml,391mIU/ml and 361mIU/ml by 3、6 and 12 months after the primary dose, respectively.Seroconversion rate were all 100% by the booster dose after one month in four groups: GMTs were 14,893mIU/ml(0、12),5,963mIU/ml(0、6),3,265mIU/ml(0、3),and 1,973mIU/ml(0、1),it had significant statistical difference.In control group,seroconversion rate were 71.0% and 71% 4 weeks and 6 months after the primary dose respectively and were 100% by one month after the booster dose; GMTs were 158mIU/ml、152mIU/ml and 1,104mIU/ml respective. The GMT protective level was over 12 time after receiving one dose of Healive D○R inactivated Hepatitis A vaccine. 0、1 immunization schedule can be used to accelerate the immunity, 0、3,0、6 and 0、12 schedules can be flexibaly applied according to requirements of diferent population, the 0、12 months is the best schedule..