Studies on the pharmacokinetics and bioavailability of disodium oleanolic acid phosphate

This paper was focused on the studies of pharmacokinetics and bioavailability of disodium oleanolic acid phosphate(OLANa 2)in rats by the HPLC method. The experimental results showed that the concentration time curves of OLANa 2 after iv of 40,50, 60 mg/kg fitted in a two compartment open model, and the elimination of OLANa 2 from plasma was in accordance with liner kinetics. The concentration time curve of OLANa 2 in rats fitted in a one compartment open model with first order absorption after oral administration and hepatic portal vein injection. The drug was administrated to the rats via ig, iv and hepatic portal vein injection crossly, the absolute bioavailability was 22 03%, the first pass effect of the liver was 11 11% and about 66 86% of the drug was not absorbed or was metabolized in the gastrointestinal tract.