Suppression of Levodopa-induced Dyskinesia in Parkinson's Disease

Aim:To evaluate the efficacy,optimal doses and side effects of clozapine for treating levodopa induced dyskinesia in parkinsonian patients.Methods:Increasing daily doses of clozapine were given to 12 patients with Parkinson's disease and levodopa induced dyskinesia.The severity of dyskinesia and parkinsonian motor disability were measured respectively by using UPDRS score and WBC counts were moniored before and after the clozapine treatment.Results:Clozapine reduced the levodopa induced dyskinesia in 11 out of 12 patients(91 7%).There is a significant improvement of the dyskinesia after clozapine treatment at daily doses of 50±51 mg,without aggravation of parkinsonian motor disability and changes of WBC counts.Conclusion:Clozapine at daily doses of 50 mg is safely to be used and significantly improves levodopa induced dyskinesia without worsening parkinsonian motor disability.