Secondary plasma cell leukemia treated with bortezomib-based regimens:one case report and literature review

Objective:To explore the effecti of bortezomib-based regimenon on plasma cell leukemia.Method:Repart one case of secondary plasma cell leukemia were treated with bortezomib-based regimen.The literature was reviewed on the bortezomib-based therapy for PCL.Result:The patient who was initially diagnosed as multiple myeloma,and was treated many times including auto-stem cell transplantation.After relapsed two times,the patient was progressed to secondary plasma cell leukemia.The patient was achieved satisfactory response was after treated with bortezomib-based regimen.The literature review found that there was a high remission rate and good tolerance by bortezomib-based regimen for PCL.Conclusion:Bortezomib-based regimencan achieve a satisfactory remission rate and could be first-line therapy for PCL,though long term remission required.