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2014•Journal of International Reproductive Health/Family PlanningRequires access

H19 Gene and Its Significance in Assisted Reproductive Technology

Yan Yong

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Abstract

Although assisted reproductive technology(ART) has been widely used in the infertile treatment now,there are potential effects on ART safety,such as the potential changes in epigenetics in ART offspring,especial those ART techniques including ICSI and IVF-ET. It is necessary to study further whether those potential epigenetic changes adversely affect offspings. H19 gene,as a maternal gene,is one of the imprinting genes which were firstly identified. Research showed that H19 gene variation was associated with the epigenetic changes of offspring. In this paper,the relationship between H19 gene and ART safety was reviewed.

About this research paper

What this paper is about

Although assisted reproductive technology(ART) has been widely used in the infertile treatment now,there are potential effects on ART safety,such as the potential changes in epigenetics in ART offspring,especial those ART techniques including ICSI and IVF-ET. It is necessary to study further whether those potential epigenetic changes adversely affect offspings. H19 gene,as a maternal gene,is one of the imprinting genes which were firstly identified. Research showed that H19 gene variation was associated with the epigenetic changes of offspring. In this paper,the relationship between H19 gene and ART safety was reviewed.

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Available abstract

Although assisted reproductive technology(ART) has been widely used in the infertile treatment now,there are potential effects on ART safety,such as the potential changes in epigenetics in ART offspring,especial those ART techniques including ICSI and IVF-ET. It is necessary to study further whether those potential epigenetic changes adversely affect offspings. H19 gene,as a maternal gene,is one of the imprinting genes which were firstly identified. Research showed that H19 gene variation was associated with the epigenetic changes of offspring. In this paper,the relationship between H19 gene and ART safety was reviewed.

Key concepts: Epigenetics, Offspring, Assisted reproductive technology, Biology, Genomic imprinting, Gene, Reproductive technology, Epigenesis

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