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2003•Chinese Journal of Clinical NeurosciencesRequires access

bFGF Protects Neonatal Rats From Hypoxi-ischemic Brain Damage by Downregulation Caspase-3

Wanc Ju

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Abstract

Aim:To explore the effect of bFGF on caspase-3 brotein and DNA fragmentation in later time after neonatal rat hypoxic-ischemic brain damage.Methods:caspase-3 protein and DNA fragmentation were measured by using immunohistochemistry and TUNEL.Results:①caspase-3 average OD values were significantly lower in bFGF group 1 (0.357±0.093) compared with those in control group 1 (0.371±0.042) P 0.05。 ②TUNEL positive cell counts were significantly lower in bFGF group 1 (4.20±1.30)compared with those in control group 1 (9.80±1.92), P 0.05.③There were no differences among the other: two groups P 0.05。Conclusion: It is suggested that bFGF might protect neuronal against apoptosis by down-regulation caspase-3 protein expression and followed DNA fragmentation,so a long and continue policy must be used.

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What this paper is about

Aim:To explore the effect of bFGF on caspase-3 brotein and DNA fragmentation in later time after neonatal rat hypoxic-ischemic brain damage.Methods:caspase-3 protein and DNA fragmentation were measured by using immunohistochemistry and TUNEL.Results:①caspase-3 average OD values were significantly lower in bFGF group 1 (0.357±0.093) compared with those in control group 1 (0.371±0.042) P 0.05。 ②TUNEL positive cell counts were significantly lower in bFGF group 1 (4.20±1.30)compared with those in control group 1 (9.80±1.92), P 0.05.③There were no differences among the other: two groups P 0.05。Conclusion: It is suggested that bFGF might protect neuronal against apoptosis by down-regulation caspase-3 protein expression and followed DNA fragmentation,so a long and continue policy must be used.

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Available abstract

Aim:To explore the effect of bFGF on caspase-3 brotein and DNA fragmentation in later time after neonatal rat hypoxic-ischemic brain damage.Methods:caspase-3 protein and DNA fragmentation were measured by using immunohistochemistry and TUNEL.Results:①caspase-3 average OD values were significantly lower in bFGF group 1 (0.357±0.093) compared with those in control group 1 (0.371±0.042) P 0.05。 ②TUNEL positive cell counts were significantly lower in bFGF group 1 (4.20±1.30)compared with those in control group 1 (9.80±1.92), P 0.05.③There were no differences among the other: two groups P 0.05。Conclusion: It is suggested that bFGF might protect neuronal against apoptosis by down-regulation caspase-3 protein expression and followed DNA fragmentation,so a long and continue policy must be used.

Key concepts: DNA fragmentation, TUNEL assay, Apoptosis, Fragmentation (computing), Caspase 3, Downregulation and upregulation, Immunohistochemistry, Andrology

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