Study on pharmacokinetics of isoniazid in dog after a high oral dose

Objective To study the pharmacokinetics of isoniazid in dog after a high oral dose.Methods Cross-over randomized design (two periods) was employed. one group was supplied with a high oral dose, while the other was supplied with common oral dose, and pharmacokinetic parameters were calculated and compared.Results The pharmacokinetics of isoniazid was fitted to a one-compartment model with first order absorption. Time to peak plasma coneentration were 2.23±0.78h and 0.96±0.32h.Elimination half life were 0.98±0.16h and 0.22±0.09h. The result of statistical analysis showed significant differeence(P0.05).Conclusions Isoniazid after a high oral dose in pharmacokinetics parameters were changed, time to peak plasma concentration and elimination half life were delayed.