1999•Chinexe Journal of PediatricsRequires access

A study on protective effect of bFGF on hypoxicischemic brain damage in neonatal rats

Yu-Kun Han

Abstract

Objective To explore the protective effect of basic fibroblast growth factor (bFGF) on hypoxicischemic brain damage (HIBD) in neontal rats Methods The HIBD models were established with 7 day old Wistar rats Body weights, mortalities and the degree of brain damage in HIBD rats treated with bFGF were compared with that in HIBD rats without the treatment of bFGF (control group) The effect on apoptosis of neurons was observed by terminal deoxynucleotidyl transferase mediated dUTPbiotin nick end labelling (TUNEL) staining. Results The body weight in bFGF treatment group was significantly higher than that in control group (124) g and (64) g, respectively (P0001); The death rate in bFGF treatment group (5%) was much lower than that in control group (62%, P001); the average number of positive cells in bFGF treatment group (30/500 cells) was significantly lower than that in control group (159/500 cells) (P0001) Conclusion The results verified the protective efficacy of bFGF on HIBD Rats,

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Key concepts: TUNEL assay, Basic fibroblast growth factor, Brain damage, Terminal deoxynucleotidyl transferase, Apoptosis, Endocrinology, Internal medicine, Immunohistochemistry