Clinical Significance of the Expression of Urokinase Type Plasminogen Activator and Plasminogen Activator Inhabitor in Cervical Carcinomas

Objective To investigate the significance of the expression of urokinase type plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1) in plasma and tissue in occurrence,progression and invasion in cervix carcinomas.Methods The levels of uPA and PAI-1 in plasma and tissue was detected by ELISA in 42 cases of cervix carcinoma and 10 cases of benign uterine tumor as control.The differences were compared in benign and malignant diseases,before and after operations,clinical stages and pathologic types.Results The levels of uPA and PAI-1 in plasma of cervical carcinomas were obviously higher than those of control group.They descended after radical surgery.Compared with the group of no pelvic lymph node metastasis,the serous uPA levels of pelvic lymph node metastasis group was obviously higher,P0.05.The levels of uPA and PAI-1 in cancer tissues were higher than those in tissues beside carcinomas.Compared with normal cervix,the level of uPA in cervical intraepithelial neoplasm and squamous cervical carcinomas was significantly different.The level of uPA in adenocarcinomas was higher than that in squamous carcinomas.Conclusions Monitoring the levels of uPA and PAI-1 in cervical carcinomas may evaluate the extent of cancer invasion, lymph node metastasis and prognosis.