Study of risk prediction of cerebral infarction after transient ischemic attack

Objective To investigate the value of ABCD2 score and ABCD2 score combination with diffusion-weighted imaging(DWI) and magnetic resonance angiography(MRA) on predicting cerebral infarction in patients with carotid artery transient ischemic attack(TIA).Methods The ABCD2 score and ABCD2 +DWI+MRA score were applied to 182 TIA patients,and the rate of cerebral infarction at 2nd d,7th d and 30th d after TIA was observed.The predictive accuracy of ABCD2 score and ABCD2+DWI+MRA score were quantified by receiver operator characteristic(ROC) curve.Results There were 56 cases(30.8%) had cerebral infarction within 30 d,while 42 cases(23.1%) occurred within 7 days,19 cases(10.4%) occurred within 2 days,and there was no cerebral hemorrhage in the group.Compared with low risk group,the rate of cerebral infarction in moderate risk group and high risk group were significently higher at the time points(all P0.05).The rates of cerebral infarction with abnormal DWI were significantly higher than that in patients with normal DWI at each time point(all P0.05).At 30th d,The rate of cerebral infarction in patients with intracal arterial stenosis≥50% was significantly higher than that in patients with intracal arterial stenosis50%(P0.05).The rates of cerebral infarction in low risk group with abnormal DWI and intracal arterial stenosis≥50% were significantly higher than that in patients with normal DWI and intracal arterial stenosis50%(all P0.05).The area under curve of ABCD2 +DWI+MRA score at 2nd d,7th d and 30th d were significantly higher than those in ABCD2 score(all P0.001).Conclusion The ABCD2 score combination with DWI and MRA can improve the predictive accuracy of cerebral infarction.