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Study on Pharmacokinetics of Melatonin in Beagle Dogs

Haixia He, Yang Yong, HE Qingquan

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Abstract

OBJECTIVE:To study pharmacokinetic parameters of melatonin tablet in beagle dogs.METHODS:A single oral dose of3mg melatonin tablet was given to6beagle dogs,drug concentrations in plasma were determined by HPLC method,the pharmacokinetic parameters were calculated by3P97pharmacokinetic program.RESULTS:The concentration-time curves of melatonin fitted two compartment model in the beagle dogs.The t 1/2Ka 、t 1/2Ke 、t max 、C max 、CL and AUC (0～T) were(0.16±0.10)h、(1.21±0.52)h、(0.50±0.18)h、(11.27±3.77)ng/ml、(0.13±0.04)L/h and(25.23±7.71)(ng·h)/ml re-spectively.CONCLUSION:It is rapid to absorb melatonin and initiate sleep in beagle dogs,but it's hold-time is short.

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What this paper is about

OBJECTIVE:To study pharmacokinetic parameters of melatonin tablet in beagle dogs.METHODS:A single oral dose of3mg melatonin tablet was given to6beagle dogs,drug concentrations in plasma were determined by HPLC method,the pharmacokinetic parameters were calculated by3P97pharmacokinetic program.RESULTS:The concentration-time curves of melatonin fitted two compartment model in the beagle dogs.The t 1/2Ka 、t 1/2Ke 、t max 、C max 、CL and AUC (0～T) were(0.16±0.10)h、(1.21±0.52)h、(0.50±0.18)h、(11.27±3.77)ng/ml、(0.13±0.04)L/h and(25.23±7.71)(ng·h)/ml re-spectively.CONCLUSION:It is rapid to absorb melatonin and initiate sleep in beagle dogs,but it's hold-time is short.

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Available abstract

OBJECTIVE:To study pharmacokinetic parameters of melatonin tablet in beagle dogs.METHODS:A single oral dose of3mg melatonin tablet was given to6beagle dogs,drug concentrations in plasma were determined by HPLC method,the pharmacokinetic parameters were calculated by3P97pharmacokinetic program.RESULTS:The concentration-time curves of melatonin fitted two compartment model in the beagle dogs.The t 1/2Ka 、t 1/2Ke 、t max 、C max 、CL and AUC (0～T) were(0.16±0.10)h、(1.21±0.52)h、(0.50±0.18)h、(11.27±3.77)ng/ml、(0.13±0.04)L/h and(25.23±7.71)(ng·h)/ml re-spectively.CONCLUSION:It is rapid to absorb melatonin and initiate sleep in beagle dogs,but it's hold-time is short.

Key concepts: Beagle, Melatonin, Pharmacokinetics, Pharmacology, Medicine, Plasma concentration, Chemistry, Internal medicine

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