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The expression of survivin and its clinical significance in hepatocellular carcinoma

Ming-hui Mei

Abstract

Objective:To investigate the expressions and significance of survivin mRNA in hepatocellular carcinoma(HCC) tissues.Methods:RT-PCR was used to detect the expression of survivin mRNA in samples of HCC tissue from 32 patients.Results:The expression of survivin mRNA in the HCC tissues was significantly higher,expression rate was 65.6%,no expression was detectable in paratumor tissue.There was significant correlation between the expression of survivin mRNA in HCC and the tumor thrombus in portal vein(P0.05).Conclusion:The survivin mRNA high expression is of potential value in judging invasion and progression of HCC.

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Available abstract

Key concepts: Survivin, Hepatocellular carcinoma, Messenger RNA, Clinical significance, Medicine, Cancer research, Portal vein, Oncology