2008•Zhongguo tangniaobing zazhiRequires access

AngiotensinII receptor blocker induces the activation of peroxisome proliferator-activated receptor gamma

MU Yi-mi

Abstract

Objective To observe the effect of angiotensin Ⅱ receptor blockers(ARBs)on peroxisome proliferator-activated receptor gamma(PPAR-γ)and to explore its mechanism for improving glucose and lipids metabolism.Methods Dual-luciferase gene reporting system was used to reflect PPAR-γ promoter activation by irbesartan and telmisartan.RT-PCR was used to reflect PPAR-γ mRNA by activation of irbesartan and telmisartan.Results Irbesartan and telmisartan may increase COS-7 cells PPAR-γ promoter expression and increase 3T3-L1 cells PPAR-γ mRNA expression in dose and time-dependent manners.Conclusions ARB may activate PPARs system to play a role in improving the glucose and lipids metabolism.

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Key concepts: Telmisartan, Irbesartan, Peroxisome proliferator-activated receptor, Receptor, Peroxisome, Chemistry, Endocrinology, Internal medicine