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[Effect of anticancer polypeptide from Buthus Martensii venom on immune function in the H22-bearing mice].

Yang Jb, Li Xw, Dong Wh, Kong Th, Song Hx, Zheng Xy, Liu Gt

Abstract

OBJECTIVE: To observe the effect of anticancer polypeptide from Buthus Martensii Venom (APBMV) on Immune function in the H22-bearing mice. METHODS: The MTT colorimetric method, homolysin assay, lymphocyte transformation test, delayed hypersensitivity assay and WBC-count of peripheral blood were used in this study. RESULTS: APBMV could obviously augment NK activity, promote proliferation of lymphocytes induced by Con A, potentiate the response of DTH induced by DNCB, antagonize the decrease of WBC in peripheral blood induced by 5-Fu in the H22-bearing mice. CONCLUSION: APBMV can obviously increase immune function in the H22-bearing mice and antagonize hypoimmunity immunodeficiency or immunodeficiency induced by chemotherapy or the tumor.

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Key concepts: Immune system, Venom, Pharmacology, Peripheral blood, Immunology, MTT assay, Lymphocyte, Apoptosis