Chemotherapy with Carboplatin and Floxuridine Combined with Radiotherapy for Advanced Esophageal Carcinoma

To study the therapeutic effect of chemotherapy with carboplatin and floxuridine combined with radiotherapy for advanced esophageal carcinoma.Two hundred and thirty-two patients with advanced esophageal carcinoma were randomized into radiotherapy plus chemotherapy group(C+R,116patients)and radiotherapy alone group(R,116patients). 60 Coγ-ray was used for all patients with a total dose of60Gy～70Gy.Chemotherapy(carboplatin plus floxuridine)was given in the first and4th week of radiotherapy in R+C group.Both groups were followed for five years.The1-,3-and5-year survival rates were73.3%,32.8%,19.8%in R+C group and55.2%,17.2%,7.8%in R group,respectively.The survival rate in R+C group were higher than that in R group(P0.01),without serious side effect in R+C group.There had no diffierence in uncontrol or relapse rate between two groups(P0.05),distant metastasis rate in R+C group was much lower than that in R group(P0.05).[Conclusion]Chemotherapy with carboplatin and floxuridine combined with radiotherapy for advanced esophageal carcinoma could improve long term survival rate and short term response of patients.