Relation between liver functional classification and the level of NO,NOS activity in liver tissue of cirrhotic patients with hepatic portal hypertension

[Objective] To study the relation between liver functional classification and the level of NO/NOS activity in liver tissue of cirrhotic patients with hepatic portal hypertension.[Methods] 56 patients with hepatic portal hypertension were divided into 3 groups(A group,B group,C group)according to the clinic grading of liver function(Child's method).19 patients without cirrhosis were taken as control group.Level of NO and activity of NOS in liver tissue were detected with functional classification chemical colorimetry.The correlation of NO level,NOS activity and liver founction class were analyzed.[Results] The level of NO and activity of NOS of cirrhotic patients with hepatic portal hypentension groups were higher than those of control group,they had positive correlation with liver functional classification(P0.01).[Conclusion] Detecting the level of NO and the activity of NOS of patients with hepatic portal hypertension can predict the degree of liver injury.