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2009•Lishizhen Medicine and Materia Medica ResearchRequires access

Study on the in vivo Recovery of Tetramethylpyrazine Phosphate in Microdialysis Probes

Qiujie Huang

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Abstract

Objective To determine the in vivo recovery of tetramethylpyrazine phosphate(TMPP) in microdialysis probes and to study its stability.Methods The recovery of TMPP was detected by retrodialysis method.The effect of flow rates and concentrations on recovery was studied.Results TMPP recovery was independent of TMPP concentration in the external medium by using retrodialysis method.TMPP recovery had good stability.Conclusion Microdialysis sampling can be used for the pharmacokinetic study of TMPP and retrodialysis method can be used for the determination of TMPP recovery in vivo.

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What this paper is about

Objective To determine the in vivo recovery of tetramethylpyrazine phosphate(TMPP) in microdialysis probes and to study its stability.Methods The recovery of TMPP was detected by retrodialysis method.The effect of flow rates and concentrations on recovery was studied.Results TMPP recovery was independent of TMPP concentration in the external medium by using retrodialysis method.TMPP recovery had good stability.Conclusion Microdialysis sampling can be used for the pharmacokinetic study of TMPP and retrodialysis method can be used for the determination of TMPP recovery in vivo.

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Available abstract

Objective To determine the in vivo recovery of tetramethylpyrazine phosphate(TMPP) in microdialysis probes and to study its stability.Methods The recovery of TMPP was detected by retrodialysis method.The effect of flow rates and concentrations on recovery was studied.Results TMPP recovery was independent of TMPP concentration in the external medium by using retrodialysis method.TMPP recovery had good stability.Conclusion Microdialysis sampling can be used for the pharmacokinetic study of TMPP and retrodialysis method can be used for the determination of TMPP recovery in vivo.

Key concepts: Tetramethylpyrazine, Microdialysis, In vivo, Chemistry, Chromatography, Recovery rate, Pharmacokinetics, Pharmacology

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