Short-term Antibody Dynamics in Children Immunized with Inactivated Domestic Hepatitis A Vaccine

With a view to evaluate the antibody titer and antibody descending trend of the domestic inactivated hepatitis A vaccine in immunized children and to find out the duration of protection induced by inactivated hepatitis A vaccine, a total of 113 children once immunized with 500U/dose of domestic inactivated hepatitis A vaccine of 0, 3 and 0, 6 month schedules were observed. Using ELISA method, the serum anti-HAV from all 113 immunized children was detected at 12, 24 and 36 months after vaccination. The results suggested that 100% of the children were anti-HAV positive at 36 months after vaccination. If the antibody 200mIU/ml is considered as positive, the positive rates were 74.1% in 0, 3 month schedule group and 85.4% in 0, 6 month schedule group.