Recent progress in the role of miRNA in hepatic stellate cells activation and the chronic hepatic diseases

Small RNA(known as microRNA,miRNA)is single-stranded non-coding RNA(18-25 nucleotides length),it regulates various proteins by targeting the 3'-untranslated region(3-UTR)of various transcripts,thus dysregulation of miRNA affects a wide range of processes such as cell proliferation and differentiation involved in organ remodeling processes.Current studies demonstrated that post-transcriptional effect of miRNA is involved in the development of chronic liver diseases,while hepatic stellate cells(HSCs)play a vital role in the primary formation of ECM and undergo progressive activation to become myofibroblasts(MFB)-like cells.The aim of this paper is to discuss the role of miRNA in hepatic stellate cells activation and the chronic hepatic diseases.