A primary study on the meaning of CD_4~+ CD_(25)~+ T cells/CD_4~+ T cells change in blood of NHL patients

Objective To study the meaning of CD+4 CD+25 T cells/ CD+4 CD+25 T cells in peripheral blood of NHL patients. Methods The peripheral blood of 15 healthy donors, 41 first diagnosed NHL patients, 16 NHL patients who have got complete response and 25 NHL patients who haven't got complete response after chemotherapy of CTOP regimen were examined by flow cytometry to define the ratio of CD+4 CD+25 T cells to CD+4 T cells. Results Phenotypic studies demonstrated increased frequency of CD+4 CD+25 T cells in peripheral blood of first diagnosed NHL patients (7.54±2.31)% compared with healthy controls (4.13±1.25)% (P 0.05). The patients who got complete response after chemotherapy of CTOP had decreased frequency(6.26±2.28)% compared with the first diagnosed patients(7.54±2.31)% (P 0.05) and patients who haven't got complete response(7.85±2.12)% (P 0.05). Conclusion There is a lower ratio of CD+4 CD+25 T cells/CD+4 T cells in peripheral blood of complete response NHL than that in peripheral blood of first diagnosed NHL patients, and patients who haven't got complete response. It indicates that the ratio of CD+4 CD+25 T cells/CD+4 T cells is relative to NHL patients' immunity and curative effect.