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Study on stability of mitomycin compatibility

Gao Yan-Li

Abstract

Objective: To study the stability of mitomyxin C in three different pH solutions. Methods: The contents of mitomyxin C in these solutions were determined by UV spectrophotometer and pH values were determined with a pH meter. Results: Accelerating test show that the t 0.9(25℃)of mitomyxin C in the solutions of pH 6.47, pH8.8 and pH 9.2 were 74 hours 371 hours and 552 hours respectively. The contents of mitomyxin C in the three solutions were all over 90% for 8 hours. Conclusion: Mitomyxin C was stable in pH6.47～9.2 solutions. The stability of mitomyxin C in acid solution was lower than in basic solution at room temperature.

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Key concepts: Compatibility (geochemistry), Mitomycin C, pH meter, Chemistry, Chromatography, Materials science, Surgery, Medicine