Expression of MDm2 and p53 in gastrointestinal stromal tumors and related prognosis

Objective To investigate the expression of MDm2 and p53 in gastrointestinal stromal tumors(GISTs)and their relationship.Methods PV6000 method of immunohistochemistry was used to detect the MDm2 and p53 expression in 52 cases of GISTs.Results The positive expression rate of MDm2 and p53 was 19.2% and 48.1% respectively.The positive expression of MDm2 was related to tumor size,primary location of tumor,grading and mitoses accounts(P0.05).The 5-year survival rate of those with or without MDm2 expression was 40.0% and 78.6% respectively with the difference being sig- nificant between the two groups(P0.05);The positive expression of p53 was related to tumor size,pri- mary location of tumor,grading,mitoses accounts and cellularity of tumor cells(P0.05).The 5-year survival rate of those with or without p53 expression was 56.0% and 85.2% respectively with the differ- ence being significant between the two groups(P0.05).Conclusion The expression of MDm2 and p53 are closely related with the prognosis of GISTs and may be considered as molecular markers for prog- nosis of GISTs.