Relationship between expression of apoptosis-related proteins and sensitivity of extra corporal chemotherapeutic drug of tumor cell in rectal carcinoma

Objective: To explore the relationship between expression of apoptosis-related proteins and sensitivities of extracorporal chemotherapeutic drugs in rectal carcinoma.Methods: The expression levels of Survivin,bcl-2 and bax were determined immunohistochemically,and the chemosenisitivities of 9 drugs were measured by MTT assay in 48 tissue specimens of rectal carcinomas.Rseults: The obviously positive rate of Survivin,bcl-2 and bax was 72.9%,35.4% and 47.9% respectively.There was significant negative correlations between the expression of Survivin and bax(r=-0.37112,P0.01),and bcl-2 and bax(r=-0.33168,P0.01).In terms of relationship between the expression of Survivin,bcl-2,bax and inhibition rate of tumor cells,the inhibition rate for epirubicin(eADM) and cisplatin(DDP) in Survivin strong expression group was lower than that in weak group(both P0.05),but for oxaliplatin(L-OHP) the inhibition rate was increased(P0.05).The inhibition rate to 5-fluorouracil(5-Fu),paclitaxel(PTX) and eADM was significantly lower in the bcl-2 strong expression group than that in the weak group(all P0.05).There was higher inhibition rate for 5-Fu,eADM,L-OHP and methotrexate(MTX) in bax strong expression group(all P0.05).Conclusion: The expression of apoptosis-related proteins in rectal carcinoma is associated with the chemosensitivities of parts of drugs.