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2011•Chinese Journal of Clinical Oncology and RehabilitationRequires access

Observation of efficacy of tumor infiltrating lymphocytes in treatment of malignant pleural effusion

Mei-ling Kang

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Abstract

Objective To evaluate the efficacy of tumor infiltrating lymphocytes(TIL)in treatment of patients with malignant pleural effusion.Methods TILs derived from malignant pleural effusion of 30 patients were cultivated in 10% human AB type serum RPMI-1640 liquid medium,activated by rIL-2 in vitro and injected into thoracic cavities.Results CR 12(40.0%),PR 15(50.0%),NR 3(10.0%).Conclusion The result suggests that TILs derived from malignant pleural effusion have good therapeutic efficacy and is safe in patients with malignant pleural effusion and can improve the quality of life of the patients.

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Objective To evaluate the efficacy of tumor infiltrating lymphocytes(TIL)in treatment of patients with malignant pleural effusion.Methods TILs derived from malignant pleural effusion of 30 patients were cultivated in 10% human AB type serum RPMI-1640 liquid medium,activated by rIL-2 in vitro and injected into thoracic cavities.Results CR 12(40.0%),PR 15(50.0%),NR 3(10.0%).Conclusion The result suggests that TILs derived from malignant pleural effusion have good therapeutic efficacy and is safe in patients with malignant pleural effusion and can improve the quality of life of the patients.

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Available abstract

Objective To evaluate the efficacy of tumor infiltrating lymphocytes(TIL)in treatment of patients with malignant pleural effusion.Methods TILs derived from malignant pleural effusion of 30 patients were cultivated in 10% human AB type serum RPMI-1640 liquid medium,activated by rIL-2 in vitro and injected into thoracic cavities.Results CR 12(40.0%),PR 15(50.0%),NR 3(10.0%).Conclusion The result suggests that TILs derived from malignant pleural effusion have good therapeutic efficacy and is safe in patients with malignant pleural effusion and can improve the quality of life of the patients.

Key concepts: Medicine, Malignant pleural effusion, Pleural effusion, Effusion, Internal medicine, Pathology, Surgery

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