2010•PubMedRequires access

[The pharmacokinetics study on Sinomenine transdermal patch on anaesthetized Beagle dogs].

Ying-Feng Zhang, Yang Yu, Zhou Li-ling

Abstract

OBJECTIVE: To explore the pharmacokinetic of Sinomenine transdermal patch. METHODS: The plasma drug concentration of Beagle dogs was determined after administration with HPLC-UVD as analysis tools. The pharmacokinetics parameters were fitted with kinetica software package. RESULTS: The exclusive analysis method was established with the following pharmacokinetics parameters: T (peak) = 8 h, Cmax = 366 ng/mL, MRT = 13 h. The pharmacokinetic characteristics was accordance with one-order rate and two-compartment model. CONCLUSION: The method is preferable to be applied to the pharmacokinetics research and further applied pharmacological study which will play a reference role in clinical application.

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Key concepts: Beagle, Pharmacokinetics, Sinomenine, Cmax, Transdermal, Transdermal patch, Pharmacology, Medicine